Benbassat et al., Horm Metab Res 1999
(Carcinoma, Hepatocellular) :
We conclude that IL-1 alpha and TNF alpha increase circulating levels of IGFBP-1 , reflecting direct effects on hepatic IGFBP-1 mRNA abundance
Lang et al., Growth Horm IGF Res 2001
:
TNFalpha also increased IGFBP-1 in the blood ( 4-fold ) and this response was associated with an increase in IGFBP-1 mRNA expression in both liver ( 3-fold ) and kidney ( 9-fold )