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KLK3 — TNF
Text-mined interactions from Literome
Zisman et al., Eur Urol 1999
(Prostatic Hyperplasia) :
Moreover, the higher spontaneous and
PSA induced secretion of
TNFalpha in BPH patients may reflect a role for this proinflammatory cytokine in vivo
Okamoto et al., J Immunother 2000
(Adenocarcinoma...) :
Significantly less
OK-PSA encapsulated into liposomes ( Lipo-OK-PSA ) than OK-PSA alone ( 1/100 or less of OK-PSA alone ) was
required to induce IFN-gamma, tumor necrosis factor-alpha
(TNF-alpha) , TNF-beta, interleukin-1 beta (IL-1 beta), natural killer, and lymphokine activated killer activities by human peripheral blood mononuclear cells and mouse spleen cells
Bertolaccini et al., Thromb Haemost 2001
(Antiphospholipid Syndrome) :
To explore the possible
involvement of the proinflammatory and prothrombotic cytokine
TNFalpha in
APS by determining the plasma levels in patients and to test for association of TNFA promoter polymorphisms and HLA class II genotypes with both plasma TNFalpha and disease
Ohta et al., J Agric Food Chem 2007
(Orthomyxoviridae Infections) :
Furthermore,
APS increased
TNF-alpha and IFN-gamma levels in mice when compared with those of untreated mice
Yuan et al., World J Gastroenterol 2009
(MAP Kinase Signaling System) :
APS did not block the activation of extracellular signal regulated kinase or c Jun amino-terminal kinase, but inhibited the activation of p38, suggesting that
APS inhibits LPS induced production of
TNF-alpha and IL-8 mRNAs, possibly by suppressing the p38 signaling pathway
Cao et al., Int J Biol Macromol 2010
(Neoplasms...) :
Further experiments showed that
APS-3b and APS-3c could cause a concentration dependent proliferation of the splenocytes, up-regulate IFN-gamma, IL-2 and IL-6 mRNA expressions in splenocytes and
stimulate the productions of NO and
TNF-alpha in peritoneal macrophages
Ayroldi et al., Curr Pharm Des 2011
(Disease Models, Animal...) :
Tumor necrosis factor was the first successful
target of cytokine inhibition therapy for psoriasis and
PsA ( e.g., infliximab, adalimumab, and etanercept )
Tian et al., World J Gastroenterol 2012
:
APS could
increase IL-1a, IL-2, IL-6, and
TNF-a expression and decrease IL-10 levels