Gene interactions and pathways from curated databases and text-mining

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NCF1 — TNF

Text-mined interactions from Literome

Dusi et al., Eur J Immunol 2001 : Our results indicate that in monocytes the IFN-gamma- and TNF-alpha induced expression of gp91phox and p22phox, but not p47phox , requires the binding of PU.1 to gp91phox promoter
Gu et al., Exp Cell Res 2002 : A mutant p47(phox) , defective in the first Src homology 3 (SH3) domain ( p47W ( 193 ) R ), diminished JNK activation by TNFalpha
Frey et al., Circ Res 2002 : Stimulation of HPAE cells with TNF-alpha resulted in the phosphorylation of p47(phox) and its association with gp91(phox) ... Inhibition of PKCzeta by multiple pharmacological and genetic approaches prevented the TNF-alpha induced phosphorylation of p47(phox) , and its translocation to the membrane
Gertzberg et al., Am J Physiol Lung Cell Mol Physiol 2004 : TNF treatment ( 50 ng/ml for 4.0 h ) induced 1 ) p47phox translocation, 2 ) an increase in p22phox protein, 3 ) increased localization of p47phox with p22phox, 4 ) O2-* generation, and 5 ) increased permeability to albumin ... p22phox antisense oligonucleotide prevented the TNF induced effect on p22phox, p47phox , O2-*, and permeability
Dewas et al., J Immunol 2003 : TNF-alpha induces phosphorylation of p47(phox) in human neutrophils : partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony stimulating factor ... Only TNF-alpha and GM-CSF induced a clear p47(phox) phosphorylation ... A neutralizing Ab against the p55 TNF receptor, contrary to a neutralizing Ab against the p75 TNF receptor, inhibited TNF-alpha induced p47(phox) phosphorylation
Li et al., Mol Cell Biol 2005 : Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells : role of p47phox phosphorylation and binding to TRAF4 ... Thus, both p47phox phosphorylation and TRAF4 are required for acute TNF-alpha signaling
Frey et al., J Biol Chem 2006 : ROS production was the result of TNFalpha activation of Ser phosphorylation of NADPH oxidase subunit p47(phox) and its translocation to EC membranes
Dang et al., FASEB J 2006 : We found that IL-10 selectively inhibited GM-CSF- but not TNFalpha induced p47PHOX phosphorylation in a concentration dependent manner
Gauss et al., J Leukoc Biol 2007 : Pharmacological inhibitors of NF-kappaB activation blocked TNF-alpha induced up-regulation of NCF1 , NCF2, and CYBB message, which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production
Yu et al., Zhonghua Yi Xue Za Zhi 2009 : TNF-alpha treatment up-regulated the p47(phox) mRNA expression by 212.8 %, and obviously increased the p47(phox) protein expression ; and alpha-ZAL pretreatment attenuated the TNF-alpha induced p47(phox) mRNA expression by 63.0 %, and also markedly inhibited the p47(phox) protein expression
Lee et al., Am J Pathol 2009 (Tracheitis) : In addition, HO-1 overexpression inhibited TNF-alpha induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression, adherence of THP-1 cells, generation of interleukin-6, p47(phox) translocation, and nuclear factor-kappaB activation
Kilpatrick et al., J Leukoc Biol 2010 : In adherent neutrophils, TNF triggered a time dependent association of delta-PKC with p47phox , which was associated with p47phox phosphorylation, indicating a role for delta-PKC in regulating O ( 2 ) ( - ) production at the level of p47phox
Lee et al., J Nutr Biochem 2013 (Pneumonia) : In addition, EGCG also attenuated TNF-a induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor (ATF)2 phosphorylation
Huang et al., J Huazhong Univ Sci Technolog Med Sci 2012 : In vitro TNF-a increased superoxide production and p47(phox) expression in HAECs, and such increases could be ameliorated by the specific PKC-? inhibitor
Spencer et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : In vivo, c-Src-KO mice also had impaired TNF-a and NF-?B responses following partial lobar liver I/R. Studies in NOX1 and p47(phox) knockout primary hepatocytes demonstrated that both NOX1 and p47(phox) are partially required for H/R mediated TNF-a production ... Cumulatively, these results demonstrate that NOX2 and its activator subunits ( p47(phox) and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly, in the absence of Kupffer cells and NOX2, NOX1 played a dominant role in TNF-a production following hepatic I/R
Strieter et al., Science 1989 : Human endothelial cells produced a neutrophil chemotactic factor ( NCF ) upon stimulation with tumor necrosis factor-alpha (TNF-alpha) , interleukin-1 beta (IL-1 beta), or lipopolysaccharide (LPS)