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HLA-G — IL10

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL10 → HLA-G (decreases) Mitsdoerffer et al., J Neuroimmunol 2005*
  Evidence: Importantly, functional experiments demonstrated that monocyte-derived HLA-G inhibits both Th1 (IFN-gamma, IL-2) and Th2 (IL-10) cytokine production by antigen-stimulated autologous CD4 T cells.

Text-mined interactions from Literome

Steck et al., Zentralbl Gynakol 2002 : The suppressive effect of HLA-G and HLA-E on the secretion of TNF-alpha ( Th1 cytokine ), IL-10 ( Th2 cytokine ) and IL-8 ( chemokine ) by immature DC could be interpreted as further evidence for the central immunotolerance role of HLA-G and HLA-E during early pregnancy
Rizzo et al., J Allergy Clin Immunol 2005 (Asthma) : The study was designed to investigate whether this impaired IL-10 production can affect the expression and the secretion of soluble HLA-G ( sHLA-G ) -1/HLA-G5 molecules
Selmani et al., Stem Cells 2008 : Our data show that MSCs secrete the soluble isoform HLA-G5 and that such secretion is interleukin-10 dependent
Blanco et al., Hum Reprod 2008 : Interleukin (IL)-10 , a cytokine associated with normal pregnancy, increased the expression of HLA-G by DSC ( P < 0.00001 ), whereas IL-2, a cytokine involved in spontaneous abortion, showed no effect
Monsiváis-Urenda et al., J Clin Immunol 2011 (Lupus Erythematosus, Systemic) : In addition, monocytes from SLE patients showed a diminished induction of HLA-G expression in response to stimulation with IL-10
Zhao et al., PloS one 2013 : To analyze the effects of IL-10 on the HLA-G expression and the apoptosis of trophoblasts infected with Toxoplasma gondii ... IL-10 regulates HLA-G expression in T. gondii infected trophoblasts