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GRB2 — STAT3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database ErbB1 downstream signaling:
GRB2 (GRB2)
→
STAT3 (STAT3)
(modification, inhibits)
Zhang et al., Biochem J 2003*, Shi et al., J Biol Chem 2004*, Sadowski et al., Nature 1993*, Coffer et al., Biochem Biophys Res Commun 1995*, Ruff-Jamison et al., J Biol Chem 1994*, Zhong et al., Science 1994, Ruff-Jamison et al., Science 1993*, Silvennoinen et al., Science 1993*, Sadowski et al., Science 1993*, Leaman et al., Mol Cell Biol 1996*, David et al., J Biol Chem 1996*, Park et al., Proc Natl Acad Sci U S A 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database IL6-mediated signaling events:
STAT3 (dimer)/FOXO1 complex (STAT3-FOXO1)
→
GRB2/SOS1/GAB family/SHP2 complex (GRB2-SOS1-GAB1_GAB2-PTPN11)
(transcription, activates)
Kortylewski et al., J Biol Chem 2003, Wegenka et al., Mol Cell Biol 1993, Schaper et al., Biochem J 1998
Evidence: mutant phenotype, reporter gene, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., Biochem J 2003
:
Grb2 regulates
Stat3 activation negatively in epidermal growth factor signalling ... In contrast, depletion of
Grb2 by RNA interference substantially
increases Stat3 tyrosine phosphorylation induced by EGF ... Indeed,
Grb2 inhibits the interaction between
Stat3 and EGFR by competitive binding to the EGFR ... Taken together, our results demonstrate that, in EGF signalling,
Grb2 regulates
Stat3 activation negatively at the receptor level
He et al., J Virol 2010
:
We have previously demonstrated that the activation of Sf-Stk, recruitment of a
Grb2/Gab2/Stat3 signaling complex, and
induction of Pu.1 expression by
Stat3 are required for the development of the early stage of Friend disease both in vitro and in vivo