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EGFR — SLC22A3
Text-mined interactions from Literome
Murillo et al., Oncogene 2005
:
Inhibition of
EGFR does not
block the
epithelial-mesenchymal transition (EMT) induced by TGF-beta1 in hepatocytes, which indicates that activation of EGFR plays an essential role in impairing apoptosis, but it is dispensable for the EMT process
Heijink et al., Am J Respir Cell Mol Biol 2010
:
We propose that TGF-beta secretion and dysregulated
EGFR signaling may increase epithelial vulnerability to allergens and
trigger the induction of
EMT , a hitherto unrecognized contributor to airway remodeling in asthma
Cowden Dahl et al., Neoplasia (New York, N.Y.) 2009
(Disease Progression...) :
Importantly, overexpression of the
epidermal growth factor receptor (EGFR) in ovarian cancer correlates with poor disease outcome and
induces EMT in ovarian cancer cells
Reischauer et al., PLoS Genet 2009
:
Further, we found that epidermal neoplasia and
EMT in pen/lgl2 mutant epidermal cells is
promoted by
ErbB signalling, a pathway of high significance in human carcinomas
Zuo et al., Breast Cancer Res 2010
(Breast Neoplasms...) :
To define the potential inter-mediate steps between mPRalpha and PI3K, we demonstrated that mPRalpha, caveolin-1 (Cav-1), and epidermal growth factor receptor (EGFR) are colocalized in the membrane of caveolar vesicle and the P4-repressed
EMT in MB468 cells can be
blocked by
EGFR inhibitor ( AG1478 ) and PI3K inhibitor ( wortmannin )
Gan et al., Oncogene 2010
(MAP Kinase Signaling System...) :
Knockdown of endogenous Snail also prevents
EGFR mediated downregulation of E-cadherin,
EMT and cell migration
Wendt et al., Oncogene 2010
(Breast Neoplasms...) :
Mechanistically,
EMT induced by TGF-ß
increased cell-surface levels of
EGFR and prevented its physical interaction with E-cadherin, leading instead to the formation of oncogenic signaling complexes with TßR-II
Comamala et al., Br J Cancer 2011
(Carcinoma...) :
Our findings suggest that CA125/MUC16
plays a role in
EMT , presumably through its interaction with E-cadherin and ß-catenin complexes and by modulating
EGFR and its downstream signalling pathway in NIH : OVCAR3 cells
Al Moustafa et al., Front Biosci (Schol Ed) 2012
(Carcinoma...) :
The purpose of this review is to summarize current information regarding the
role of
EGF-R signaling on
EMT during human cancer progression and metastasis
Maseki et al., Br J Cancer 2012
(Carcinoma...) :
These results suggest that
EMT in the gefitinib-resistant cells is
mediated by the downregulation of
EGFR and compensatory activation of Akt/GSK-3ß/snail pathway