Li et al., Eur J Pharmacol 1998
(Multiple Sclerosis) :
Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Katunuma et al., Adv Enzyme Regul 1998
(Bone Resorption) :
The ovalbumin dependent production of immunoglobulins ( IgE and IgG1 ) and of the corresponding interleukin ( IL-4 ) was suppressed by cathepsin B inhibitors, while the production of IgG2a and interferon ( INF-gamma ) was increased