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IL17A — IL4

Text-mined interactions from Literome

Chabaud et al., Arthritis Rheum 1999 (Arthritis, Rheumatoid) : The secretion of IL-17 by synovium was measured in the presence of IL-4 , IL-13, and IL-10
Lenarczyk et al., Clin Exp Immunol 2000 : We therefore investigated the in vitro IL-17 response to a variety of mitogens and antigens, and compared the IL-17 response to interferon-gamma (IFN-gamma), IL-4 , IL-10 and TNF-alpha
Park et al., Nat Immunol 2005 (Inflammation...) : Furthermore, both IL-4 and interferon-gamma negatively regulated T helper cell production of IL-17 in the effector phase
Schnyder-Candrian et al., J Exp Med 2006 (Asthma) : Furthermore, IL-17 is regulated in an IL-4 dependent manner since mice deficient for IL-4Ralpha signaling showed a marked increase in IL-17 concentration with inhibited eosinophil recruitment ... Therefore, endogenous IL-17 is controlled by IL-4 and has a dual role
Sarkar et al., Arthritis Rheum 2007 (Arthritis, Experimental...) : T cell IL-17 production after collagen rechallenge was not inhibited by a lack of IL-23, since IL-4 mediated suppression of IL-17 was not reconstituted by IL-23, an otherwise potent inducer of IL-17 production by T cells
Hirota et al., J Exp Med 2007 (Arthritis, Experimental...) : The CCL20 production by synoviocytes is augmented in vitro by IL-1beta, IL-17 , or tumor necrosis factor alpha, and is suppressed by IFN-gamma or IL-4
Eyerich et al., J Allergy Clin Immunol 2009 (Dermatitis, Atopic...) : In vivo, additional application of staphylococcal enterotoxin B induced IL-17 in APT reactions, whereas IL-4 , IFN-gamma, and IL-10 were marginally regulated
Veenbergen et al., Ann Rheum Dis 2010 (Arthritis, Experimental) : No significant differences were observed in anti-BCII antibodies, but the aggravation was accompanied by decreased IFNgamma ( -30 % ) and IL-4 ( -44 % ) and increased IL-17 ( +84 % ) production by splenic CD3 ( + ) T cells
Yi et al., Blood 2009 (Graft vs Host Disease...) : However, absence of interferon-gamma (IFN-gamma) in CD4 ( + ) T cells resulted in augmented Th2 and Th17 differentiation and exacerbated tissue damage in lung and skin ; absence of both IL-4 and IFN-gamma resulted in augmented Th17 differentiation and preferential, although not exclusive, tissue damage in skin ; and absence of both IFN-gamma and IL-17 led to further augmentation of Th2 differentiation and idiopathic pneumonia
Park et al., J Immunol 2009 (Asthma...) : This study also showed that the inhibition of IL-17 activity with anti-IL-17 Ab remarkably reduced the increased numbers of inflammatory cells of the airways, airway hyperresponsiveness, and the increased levels of IL-4 , IL-5, and IL-13 in bronchoalveolar lavage fluid and OVA-specific IgE in serum
Sarkar et al., Arthritis Res Ther 2009 (Arthritis, Experimental...) : The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-gamma and IL-4
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Wallis et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : Peripheral blood mononuclear cells were activated under Th17 stimulating conditions in the presence or absence of IL-4 , and IL-17 production was measured by both enzyme linked immunosorbent assay ( ELISA ) and flow cytometry ... In healthy individuals, IL-4 significantly inhibited IL-17 production by cells from subjects with the I/I genotype ( P = 0.0079 ) and the I/V genotype ( P = 0.013 ), but not the V/V genotype ( P > 0.05 )
Shreiner et al., Infect Immun 2012 (Neovascularization, Pathologic) : The process was partially mediated by CD4+ T cells and by interleukin-4 (IL-4) production, did not require eosinophils, and was independent of gamma interferon ( IFN-? ) and IL-17
Ten Berge et al., Rheumatology (Oxford) 2012 (Granuloma...) : Enhanced IL-17A expression in granulomas and the presence of IL-17A ( + ), IL-17A ( + ) IFN-? ( + ) and IL-17A ( + ) IL-4 ( + ) memory Th cells in the circulation and BAL indicate Th17 cell involvement in granuloma induction or maintenance in sarcoidosis
Sandoghchian Shotorbani et al., Iran J Immunol 2011 : Objective : To examine the effect of IL-4 on IL-17 production and its effect in Collagen Induced Arthritis ( CIA ) mice ... Conclusion : IL-4 can be involved in the production of IL-17 at especially the peak of CIA
Choi et al., J Invest Dermatol 2013 (Hypopigmentation) : Despite the lack of a direct inhibition of melanin pigment synthesis, IFN? and IL-17A increased the synthesis of an antimelanogenic cytokine IL-6 in NHMs. IFN? activated signal transducers and activators of transcription 1 ( STAT1 ) and STAT3 phosphorylation in NHMs, and IL-4 increased the STAT3 and STAT6 phosphorylation