◀ Back to NOX4
NOX4 — SMAD3
Text-mined interactions from Literome
Cucoranu et al., Circ Res 2005
(Fibrosis) :
Because activation of small mothers against decapentaplegic ( Smads ) 2/3 is critical for myofibroblast conversion in response to TGF-beta1, we also determined whether
Nox4 affects
Smad 2/3 phosphorylation ... Depletion of
Nox4 but not Nox5
inhibits baseline and TGF-beta1 stimulation of
Smad 2/3 phosphorylation by 75+/-5 % and 68+/-3 %, respectively ( n=7, P < 0.0001 )
Ismail et al., Am J Physiol Lung Cell Mol Physiol 2009
:
Smad inhibition does not but the phosphatidylinositol 3-kinase (PI3K) signaling pathway inhibitor LY-294002 does
inhibit NOX4 and IGFBP-3 gene expression, IGFBP-3 secretion, and cellular proliferation resulting from hypoxia
Boudreau et al., Free Radic Biol Med 2012
:
Nox4 transcriptional regulation by TGF-beta was
SMAD3 dependent based on the effect of constitutively active SMAD3 increasing Nox4 promoter activity, whereas dominant negative SMAD3 or SIS3, a SMAD3-specific inhibitor, had the opposite effect