Gene interactions and pathways from curated databases and text-mining

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ENO4 — PLG

Text-mined interactions from Literome

López-Alemany et al., Am J Hematol 2003 (Adenocarcinoma...) : In the present study we have examined the role of alpha-enolase in plasminogen activation on the cell surface
Bizik et al., Cell Death Differ 2004 (Necrosis) : We also identified alpha-enolase mediated plasminogen activation as the major extracellular proteolytic executor of necrotic cell death
Pancholi et al., Microb Pathog 2003 : The increased plasminogen binding in the presence of free enolase indicated the presence of an enolase/SEN-specific receptor on the pharyngeal cell surface
Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Plasminogen/plasmin regulates alpha-enolase expression through the MEK/ERK pathway ... Pla mimics Plg stimulated alpha-ENO expression through its serine protease activity, suggesting that conversion of Plg to active Pla is required ... Altogether, our data show that Plg/Pla regulates alpha-ENO expression through the MEK/ERK pathway
Redlitz et al., Eur J Biochem 1995 : Moreover, immunopurified alpha-enolase enhanced plasminogen activation by tissue plasminogen activator and blocked the binding of plasminogen to alpha 2-antiplasmin, mimicking functions arising from the association of plasminogen with cells
Bergman et al., FEBS Lett 1997 (Cell Transformation, Neoplastic) : However, no difference was observed between normal and transformed cells in formation of plasmin, suggesting that upregulation of alpha-enolase may contribute to an increased metabolic capacity, but not to increased plasminogen activation