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FADS2 — SREBF1

Text-mined interactions from Literome

Matsuzaka et al., J Lipid Res 2002 : Although these data suggested that SREBP-1c regulates D5D and D6D expression, there was no difference in either the D5D or D6D mRNA level between fasted and refed normal mouse livers, indicating a mechanism for fasting induction of both desaturases ... The data suggested that D5D and D6D expression is dually regulated by SREBP-1c and PPARalpha, two reciprocal transcription factors for fatty acid metabolism, and could be involved in lipogenic gene regulation by producing PUFA
Nakamura et al., Prostaglandins Leukot Essent Fatty Acids 2003 : We recently identified sterol regulatory element ( SRE ) that is required for activation of the human D6D gene by SREBP-1c