Gene interactions and pathways from curated databases and text-mining

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PPARG — SIRT1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of NCOR1-PPARG → SIRT1 (decreases, NCOR1/PPARG Activity)
    Evidence: SIRT1 represses PPAR-gamma, a key regulator of adipogenesis, by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors)
  • OpenBEL Selventa BEL large corpus: Complex of NCOR2-PPARG → SIRT1 (decreases, NCOR2/PPARG Activity)
    Evidence: SIRT1 represses PPAR-gamma, a key regulator of adipogenesis, by docking with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid and thyroid hormone receptors)
  • WikiPathways NAD metabolism, sirtuins and aging: SIRT1 → FOXO1/FOXO3/TFAM/TFAM/PPARG (activation)

Text-mined interactions from Literome

Picard et al., Nature 2004 : Sirt1 represses PPAR-gamma by docking with its cofactors NCoR ( nuclear receptor co-repressor ) and SMRT ( silencing mediator of retinoid and thyroid hormone receptors ) ... Repression of PPAR-gamma by Sirt1 is also evident in 3T3-L1 adipocytes, where overexpression of Sirt1 attenuates adipogenesis, and RNA interference of Sirt1 enhances it
Das et al., Prostaglandins Leukot Essent Fatty Acids 2005 (Diabetes Mellitus, Type 2...) : In addition, SIRT1 repressed PPAR-gamma , and overexpression of SIRT1 attenuated adipogenesis, and upregulation of SIRT in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span ... In addition, SIRT1 repressed PPAR-gamma , and overexpression of SIRT1 attenuated adipogenesis, and upregulation of SIRT in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span
Zhang et al., J Bone Miner Res 2010 (Bone Diseases, Metabolic) : In contrast, adipocyte formation and Ppar-gamma expression in cultures were increased, and expression of the polycomb protein sirtuin ( Sirt1 ) was reduced