◀ Back to CCND1

CCND1 — VEGFA

Text-mined interactions from Literome

Favot et al., Cardiovasc Res 2003 : Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor induced decrease in expression of cyclin dependent kinase inhibitor p27 ( kip1 ) and the vascular endothelial growth factor induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G ( 1 ) -to-S transition
Favot et al., Thromb Haemost 2004 : 6 ) EHNA and RP73401 together blocked the VEGF induced increase in cyclin D1 and decrease in p21 waf1/cip1 expressions ; 7 ) Inhibition of VEGF upregulated PDE2 and PDE4 reversed the VEGF induced alterations in cell cycle protein expression, bringing back endothelial cells to a non proliferating status
Baba et al., Clin Exp Metastasis 2004 : Inostamycin inhibited activation of mitogen activated kinases ( ERK and p38 ) and elevation of cyclin D1 induced by VEGF
Cheng et al., Life Sci 2005 : The crude extract and fractionated fractions, except for Fra-2, of A. cinnamomea polysaccharides significantly decreased VEGFR2 phosphorylation on tyrosine 1054/1059, cyclin D1 promotor activity, and protein expression induced by VEGF
Yasui et al., Clin Cancer Res 2006 (Disease Models, Animal...) : In cultures of human umbilical vein endothelial cells ( HUVEC ), VEGF augmented cyclin D1 expression and cell growth
Liu et al., Lab Invest 2009 (Disease Models, Animal...) : PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of Akt in activated HSCs
Steindl-Kuscher et al., Invest Ophthalmol Vis Sci 2009 : VEGF , on the other hand, led to a reduction in cyclin D1 and to an increase in GSK 3beta and beta-catenin expression which was paralleled by an increase in RPE-specific differentiation markers
Li et al., J Huazhong Univ Sci Technolog Med Sci 2011 : VEGF stimulated Rap1 activity, phosphorylation of ERK and Akt, cyclin D1 expression and cell proliferation were repressed in HUVECs overexpressing Rap1GAP as compared to empty vector transfected control
Pedram et al., J Biol Chem 1998 : VEGF stimulated both cyclin D1 synthesis and Cdk4 kinase activity, inhibited by PD 98059 and dominant negative JNK-1