◀ Back to NOTCH4

NOTCH4 — VEGFA

Text-mined interactions from Literome

Leong et al., Mol Cell Biol 2002 : We also show that activated Notch4 inhibits vascular endothelial growth factor ( VEGF ) -induced angiogenesis in the chick chorioallantoic membrane in vivo
Hainaud et al., Cancer Res 2006 (Carcinoma...) : In venous endothelial cells, we showed that VEGF up-regulates DLL4 and presenilin, and increased the activation of Notch4 , leading to an up-regulation of ephrin B2 with a down-regulation of Eph B4
Kume et al., Histol Histopathol 2010 : For arterial specification, vascular endothelial growth factor ( VEGF ) induces expression of Notch signaling genes, including Notch1 and its ligand, Delta-like 4 (Dll4), and Foxc1 and Foxc2 transcription factors directly regulate Dll4 expression
Kiec-Wilk et al., J Physiol Pharmacol 2010 : The MAPK dependent regulation of the Jagged/Notch gene expression by VEGF , bFGF or PPAR gamma mediated angiogenesis in HUVEC ... The study analyzed the signalling pathways involved in the regulation of Jagged-1/Notch-4 expression in endothelial cells ( HUVECs ) in response to VEGF , bFGF and PPAR-gamma exogenous activator - ciglitazone ... The opposite effect of VEGF , bFGF, or ciglitazone on the Jagged-1/Notch-4 expression on HUVEC was connected with the different activation of MAPKs
Funahashi et al., Vascular cell 2011 : Overexpression of VEGF induced Notch4 and the Notch ligand, Dll4, activated Notch signaling, and altered endothelial cell morphology in a fashion similar to that induced by Notch activation ... Expression of a secreted Notch antagonist ( Notch1 decoy ) suppressed VEGF mediated activation of endothelial Notch signaling and endothelial morphogenesis
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Here, we examine whether Notch signalling mediates vascular endothelial growth factor ( VEGF ) and angiopoietin 2 (Ang2) induced vascular function ... VEGF and Ang2 induced Notch-1 IC/ Notch-4 IC protein expression in synovial explant cultures and human microvascular EC levels were further potentiated by VEGF/Ang2 stimulation in combination
Michailidis et al., Eur J Dermatol 2013 : There are reports of Notch2 receptor expression peculiarities in psoriatic skin and others, indicating that VEGF induced Notch4 overexpression promotes endothelial cell morphology alterations and that increased dermis vessel permeability histogenetically precedes the development of psoriatic lesions