Gene interactions and pathways from curated databases and text-mining

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BCL2 — IL7R

Pathways - manually collected, often from reviews:

  • BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → BCL-2 (BCL2) (modification, activates)

Text-mined interactions from Literome

Vranjkovic et al., J Leukoc Biol 2011 (HIV Infections) : In contrast, IL-7 induced Bcl-2 expression was not impaired in CD8 ( + ) CD127 ( + ) T cells from HIV ( + ) individuals