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CD40LG — FAS

Text-mined interactions from Literome

Zhang et al., Cell Immunol 1996 : It has been shown that CD40L can induce both Fas expression and susceptibility to Fas mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas mediated killing
Kuhné et al., J Exp Med 1997 : Studies with human B cells show that the binding of CD154 ( gp39, CD40L ) to CD40 recruits TNF receptor- associated factor 2 ( TRAF2 ) and TRAF3 to the receptor complex, induces the downregulation of the nonreceptor associated TRAFs in the cell and induces an increased expression of Fas on the cell surface