Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK1
(increases, MAPK1 Activity, RPS6KA5 Activity)
Evidence: Figure 1. Pathways to MUC5AC expression in COPD
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK1
(increases, MAPK1 Activity, RPS6KA5 Activity)
Evidence: several downstream substrates of ERK1/2 kinase have been identified (Brunet & Pouyssegur, 1997), including p90 ribosomal S6 kinase (p90rsk, also known as MAPK-activated protein kinase (MAPKAP-K) 1; Zhao et al. 1996) and mitogen- and stress-activated kinases (MSK) 1 and 2 (Deak et al. 1998).
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK1
(increases)
Deak et al., EMBO J 1998 Evidence: MSK1 is activated in vitro by MAPK2/ERK2 or SAPK2/p38. Endogenous MSK1 is activated in 293 cells by either growth factor/phorbol ester stimulation, or by exposure to UV radiation, and oxidative and chemical stress. The activation of MSK1 by growth factors/phorbol esters is prevented by PD 98059, which suppresses activation of the MAPK cascade, while the activation of MSK1 by stress stimuli is prevented by SB 203580, a specific inhibitor of SAPK2/p38. The activated MSK1 translocates to nucleus an...
OpenBEL Selventa BEL large corpus:
RPS6KA5
→
MAPK1
(directlyIncreases, RPS6KA5 Activity)
Evidence: PhosphoElm data from PMID 15212693