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CXCR4 — STAT3

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: STAT1-3-5 (STAT5A/STAT5B/STAT1/STAT3) → SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) (modification, collaborate)
  Vila-Coro et al., FASEB J 1999, Ahr et al., J Biol Chem 2005
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CXCR4 — STAT3 (in vivo) Vila-Coro et al., FASEB J 1999

Text-mined interactions from Literome

Huang et al., Am J Physiol Heart Circ Physiol 2011 (Myocardial Reperfusion Injury) : SDF-1 binding to its cognate receptor CXCR4 has been shown to activate STAT3 in a variety of cells ... Additionally, pretreatment with SDF-1 reduced cardiac apoptotic signaling and increased myocardial STAT3 activation following acute I/R. Inhibition of the SDF-1 receptor CXCR4 neutralized these protective effects by SDF-1 in hearts subjected to I/R. Notably, inhibition of the STAT3 pathway or use of STAT3KO hearts abolished SDF-1 induced acute protection following myocardial I/R
Jung et al., Oncogene 2013 (Carcinoma, Non-Small-Cell Lung...) : Inhibition of STAT3 by WP1066 or siSTAT3 significantly suppressed the sphere formation, but not CXCR4 expression, indicating that STAT3 is a downstream effector of CXCR4 mediated signaling
Shen et al., Tumour Biol 2013 (Neoplasm Invasiveness...) : CXCR4 mediated Stat3 activation is essential for CXCL12 induced cell invasion in bladder cancer
Heskamp et al., Neurobiol Dis 2013 (Disease Models, Animal...) : Furthermore, the neurite growth promoting and disinhibitory effects of CXCL12 were abrogated by a specific CXCR4 antagonist and by inhibition of the PI3K/AKT/mTOR-, but not the JAK/STAT3-pathway