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Ko et al., Int J Mol Med 2013
:
In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro-inflammatory cytokine release and phosphorylation of mitogen activated protein ( MAP ) kinases ( ERK , JNK and p38 ) in a human mast cell line
Cho et al., Evidence-based complementary and alternative medicine : eCAM 2013
:
Conversely, silencing of AMPK a blocked PARP cleavage and ERK activation induced by CB-PIC , while ERK inhibitor PD 98059 attenuated the phosphorylation of AMPK a in hypoxic SW620 cells, implying cross-talk between ERK and AMPK a