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IFNG — STAT5B

Text-mined interactions from Literome

Storz et al., FEBS Lett 1999 (Rhabdomyosarcoma) : By contrast, in the same cells, IFNgamma induced STAT5b activation was JAK2 dependent, indicating that this signal pathway is functional in Kym-1 cells
Hwa et al., J Biol Chem 2004 : In summary, our results provide evidence of the following in human primary dermal fibroblasts : ( a ). IFN-gamma preferentially activates STAT-5b , but, in the absence of a functional STAT-5b, STAT-5a is activated ; ( b ). IFN-gamma time-dependently up-regulates IGF-I mRNA expression ; ( c ). the regulation of IGF-I requires an active STAT-5b, and activated STAT-5a can not substitute for an inactive STAT-5b ; and ( d ). STAT-5b has an essential role in the transcriptional up-regulation of IGF-I