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CTNND1 — RAC2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hsia et al., J Cell Biol 2003
(Neoplasm Invasiveness...) :
Cell invasion was linked to transient FAK accumulation at lamellipodia, formation of a
FAK-Src-p130Cas-Dock180 signaling complex, elevated
Rac and c-Jun NH2-terminal kinase
activation , and increased matrix metalloproteinase expression and activity
Hou et al., J Biol Chem 2006
:
Dual
regulation of Rho and
Rac by
p120 catenin controls adipocyte plasma membrane trafficking
Smith et al., J Cell Biol 2008
(Neoplasm Invasiveness) :
We show that uPAR cooperates with integrin complexes containing beta ( 3 ) integrin to drive formation of the
p130Cas-CrkII signaling complex and
activation of
Rac , resulting in a Rac-driven elongated-mesenchymal morphology, cell motility, and invasion
Sharma et al., BMC cell biology 2008
:
Phosphorylation of
p130Cas initiates
Rac activation and membrane ruffling
Birukova et al., Exp Cell Res 2011
(Disease Models, Animal...) :
OxPAPC also induced
Rac dependent tyrosine phosphorylation and association of p190RhoGAP with AJ protein
p120-catenin
Vanden Borre et al., Cell Signal 2011
:
Using R743A BCAR3, a point mutant that has lost the ability to bind p130Cas, we find that
BCAR3-p130Cas complex formation is not
required for BCAR3 mediated anti-estrogen resistance,
Rac activation or discohesion of epithelial breast cancer cells
Dolfi et al., Proc Natl Acad Sci U S A 1998
:
JNK activation by
Cas and Crk was effectively
blocked by a dominant negative form of
Rac , suggesting for a linear pathway from the Cas-Crk-complex to the Rac-JNK activation