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IL18 — PI3

Text-mined interactions from Literome

Morel et al., J Biol Chem 2001 (Arthritis, Rheumatoid) : IL-18 requires NF kappa B as well as PI 3-kinase to induce VCAM-1 on RA synovial fibroblasts, suggesting that there may be two distinct pathways in IL-18 induced adhesion molecule expression
Dai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : Increased levels of NF-kappaB in the nucleus, phosphorylated IkappaB, and PI 3-kinase were confirmed in monocytes cocultured with PHA prestimulated T cells, and the levels were further increased by stimulation with IL-18
Chandrasekar et al., J Biol Chem 2005 (Hypertrophy...) : Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K) , an effect that was blocked by wortmannin and LY-294002