◀ Back to NFKB1

DEFB4B — NFKB1

Text-mined interactions from Literome

Krisanaprakornkit et al., J Immunol 2002 (MAP Kinase Signaling System) : The role of NF-kappaB in hBD-2 regulation was investigated initially due to its importance in inflammation and infection ... Nuclear translocation of p65 and NF-kappaB activation was seen in human gingival epithelial cells stimulated with F. nucleatum cell wall extract, indicating possible involvement of NF-kappaB in hBD-2 regulation ... Our results suggest that NF-kappaB is neither essential nor sufficient for hBD-2 induction, and that hBD-2 regulation by F. nucleatum is via p38 and JNK, while phorbol ester induces hBD-2 via the p44/42 extracellular signal regulated kinase pathway
Tsutsumi-Ishii et al., J Leukoc Biol 2002 : NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation ... Together, these observations indicate that NF-kappa B plays an important role in the regulation of hBD-2 gene expression in response to LPS
Tomita et al., Respirology 2002 : Lipopolysaccharide induced gene expression of hBD-2 was down-regulated by ( i ) dexamethasone, ( ii ) inhibition of NF-kappaB and AP-1, and ( iii ) intracellular calcium chelator ... These findings suggest that glucocorticoids ( GC ), but not COX inhibitors, reduce hBD-2 gene expression, while NF-kappaB , AP-1 and intracellular calcium are essential for hBD-2 expression
McDermott et al., Invest Ophthalmol Vis Sci 2003 : The NFkappaB inhibitors pyrrolidinedithiocarbamate ( PDTC ; 100 microM ), caffeic acid phenethyl ester ( CAPE ; 90 microM ), and MG-132 ( 25 microM ), blocked IL-1beta stimulated expression of hBD-2
Chung et al., Infect Immun 2004 : However, in addition, hBD-2 induction by pathogenic bacteria in both oral and foreskin keratinocytes was blocked by inhibitors of NF-kappaB
Wehkamp et al., Infect Immun 2004 : NF-kappaB- and AP-1 mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917 : a novel effect of a probiotic bacterium ... Luciferase gene reporter analyses and site directed mutagenesis experiments demonstrated that functional binding sites for NF-kappaB and AP-1 in the hBD-2 promoter are required for induction of hBD-2 through E. coli Nissle 1917
Witthöft et al., Dig Dis Sci 2005 : Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells ( CaCo2 )
Kumar et al., Microbes Infect 2006 : The Pam3Cys induced hBD2 expression was completely blocked by NF-kappaB inhibitors and partially inhibited by p38 MAP kinase and the JNK inhibitors
Voss et al., J Biol Chem 2006 (Crohn Disease) : Luciferase gene reporter analyses and site directed mutagenesis experiments demonstrated that functional binding sites for NF-kappaB and AP-1 in the hBD-2 promoter are required for NOD2 mediated induction of hBD-2 through MDP
Wehkamp et al., J Invest Dermatol 2006 : Pseudomonas aeruginosa- and IL-1beta mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1
Kanda et al., Am J Physiol Cell Physiol 2007 : These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced hBD-2 production dependent on NF-kappaB , AP-1, or STAT1 in human keratinocytes