Gene interactions and pathways from curated databases and text-mining

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FGFR2 — PGF

Pathways - manually collected, often from reviews:

  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)

Text-mined interactions from Literome

Sabbieti et al., Cell Tissue Res 2005 : In particular, pre-treatment with phorbol 12-myristate 13-acetate ( PMA ) prevents the nuclear accumulation of FGF-2 and FGFR2 in response to PGF ( 2alpha ) ... We conclude that PGF ( 2alpha ) stimulates nuclear translocation of FGF-2 and FGFR2 by a PKC dependent pathway ; we also suggest an involvement of MAPK/ERK2 in this process
Marchetti et al., J Cell Biochem 2006 : PGF2alpha increased binding of FGF-2 and FGFR2 and co-localization of reactive sites in addition to nuclear translocation at the nuclear pore complex level