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CCNG1 — IL3
Text-mined interactions from Literome
Schneider et al., J Cell Physiol 1990
:
Evidence is provided that i )
IL-3 induced day-8 CFU-S cell
cycling , evaluated by hydroxy-urea suicide, is completely abrogated when the binding of histamine to its H2 receptors is blocked by the specific antagonist oxmetidine, whereas cetirizine, a H1 receptor antagonist, is ineffective ; and ii ) the entry of day-8 CFU-S into S phase in response to IL-3 is likewise abolished when the histamine synthesis promoted by the growth factor is prevented by alpha-fluoromethylhistidine, a specific inhibitor of the histamine forming enzyme, histidine decarboxylase
Williams et al., Blood 1990
:
Thymidine suiciding studies suggest that this targeted infection is due to specific
induction of
cycling of CFC-Pre-B by IL-7 and CFU-GM by
IL-3
Testa et al., Blood 1994
(Hodgkin Disease...) :
Hypothetically, the sharp LIF decrease and
IL-3 increase during chemotherapy may
underlie the induction of stem cell
cycling and differentiation caused by hematopoietic ablation