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RALA — RALB

Pathways - manually collected, often from reviews:

• NCI Pathway Database FoxO family signaling: RAL/GDP complex (RALA_RALB) → RAL/GTP complex (RALA_RALB) (modification, collaborate)
  Essers et al., EMBO J 2004
  Evidence: assay
• Reactome Reaction: RALA → RALB (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of RALA-RALB (association, pull down) Bodemann et al., Cell 2011

Text-mined interactions from Literome

Clough et al., J Biol Chem 2002 : Calmodulin binds RalA and RalB and is required for the thrombin induced activation of Ral in human platelets
Zhu et al., J Biol Chem 2002 : Activation of RalA and RalB by growth hormone did not require the activity of JAK2 per se. Ras was also activated by GH and was required for the GH-stimulated formation of GTP bound RalA and RalB
Falsetti et al., Mol Cell Biol 2007 : Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage dependent growth and induce apoptosis and RalA to inhibit anchorage independent growth
Neyraud et al., J Biol Chem 2012 : RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane