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Giuliani et al., J Cell Sci 1999 : Nevertheless, a sustained ERK1/2 activation is not sufficient to trigger uPA upregulation and morphogenesis
Nguyen et al., J Cell Biol 1999 : Ras and MAP kinase kinase ( MEK ) were necessary and sufficient for uPA induced ERK activation and stimulation of cellular migration, as demonstrated in experiments with dominant negative and constitutively active mutants of these signaling proteins
Aguirre Ghiso et al., J Cell Biol 1999 (MAP Kinase Signaling System...) : These results indicate that dormancy of low uPAR cells may be the consequence of insufficient uPA/uPAR/alpha5beta1 complexes, which can not induce ERK1/2 activity above a threshold needed to sustain tumor growth in vivo
Kobayashi et al., J Biol Chem 2001 (MAP Kinase Signaling System...) : PMA could also activate a signaling pathway involving MEK1/ERK2/c-Jun dependent uPA expression
Webb et al., J Cell Biol 2001 (Breast Neoplasms) : ERK phosphorylation was not induced by tissue-type plasminogen activator-PAI-1 complex or by uPA-PAI-1 complex in the presence of antibodies that block uPA binding to uPAR
Kobayashi et al., Hum Cell 2001 (MAP Kinase Signaling System...) : We next asked whether the mechanism of inhibition of uPA expression by bik is due to interference with MAP kinase, since PMA could also activate a signaling pathway involving MEK/ERK/c-Jun dependent uPA expression
Jo et al., J Biol Chem 2003 : CHO-K1 cells do not express EGFR ; however, these cells demonstrated ERK activation in response to uPA , indicating the presence of an EGFR independent alternative pathway ... When CHO-K1 cells were transfected to express EGFR or a kinase-inactive mutant of EGFR, ERK activation in response to uPA was unchanged ; however, the EGFR expressing cells acquired sensitivity to AG1478
Shin et al., J Cancer Res Clin Oncol 2002 (Neoplasm Invasiveness...) : However, only inhibition of Src and ERK could block KGF stimulated secretion of uPA and MMP-9
Ahmed et al., Br J Cancer 2003 (Colonic Neoplasms...) : Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells ... In contrast, in A/S cells, uPA induction of Erk activation was not observed
Mahabeleshwar et al., J Biol Chem 2004 (Anoxia...) : However, the role of hypoxia/reoxygenation ( H/R ) on ERK1/2 mediated uPA secretion and cell motility and the involvement of p56 ( lck ) and EGF receptor in these processes in breast cancer cells is not well defined
Das et al., J Biol Chem 2004 (Breast Neoplasms...) : To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Tanaka et al., Int J Cancer 2004 (MAP Kinase Signaling System...) : IGF-I induced IGFBP-4 proteolysis by PAPP-A may enhance cell growth and invasion through IGF-I dependent Akt and ERK1/2 activation and subsequently upregulation of uPA
Rangaswami et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Wild type NIK, IKKalpha/beta, and ERK1/2 enhanced and kinase negative NIK ( mut NIK ), dominant negative IKKalpha/beta ( dn IKKalpha/beta ), and dn ERK1/2 suppressed the OPN induced NFkappaB activation, uPA secretion, pro-MMP-9 activation, cell motility, and chemoinvasion
Zhang et al., J Am Soc Nephrol 2004 (MAP Kinase Signaling System...) : Enhanced proliferation of uPAR-/- fibroblasts seems to be mediated by uPA dependent ERK signaling via an alternative urokinase receptor
Niiya et al., Oncology 2004 (Carcinoma, Small Cell...) : Involvement of ERK1/2 and p38 MAP kinase in doxorubicin induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells
Gu et al., J Cell Physiol 2005 (Arteriosclerosis...) : Stimulation with human uPA specifically induced phosphorylation of early response regulated kinase (ERK) in cells expressing human uPAR but not in sham transfected cells
Jo et al., J Biol Chem 2005 : In this study, we demonstrate that ERK activation in response to uPA follows equivalent biphasic kinetics in EGFR expressing and -deficient CHO-K1 cells
Nicholl et al., J Vasc Surg 2005 : Although uPA induced phosphorylation of both ERK1/2 and p38 MAPK was blocked by Galphai inhibition, inhibition of PI3K and Ras decreased the uPA induced phosphorylation of ERK1/2 but not p38 MAPK
Ghosh et al., J Biol Chem 2006 : Both Src and ERK1/2 were phosphorylated in response to integrin aggregation, and blocking Src kinase activity completely abrogated ERK1/2 activation and uPA induction , whereas inhibition of epidermal growth factor receptor tyrosine kinase activity did not alter uPA expression
Lee et al., Exp Mol Med 2006 (Neoplasm Metastasis...) : Regulation of hepatocyte growth factor mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines ... In contrast, SB203580 pre-treatment enhanced cell proliferation and uPA secretion due to induction of ERK phosphorylation
Wang et al., J Invest Dermatol 2006 (Carcinoma, Squamous Cell) : Functional blockade of uPA receptor (uPAR) or inhibition of p70S6 kinase, but not inhibition of Ras/ERK signaling, suppresses this GM3 induced stimulation of cell proliferation
Kleiner et al., FEBS J 2007 (MAP Kinase Signaling System) : Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc dependent Erk signaling
Onwuegbusi et al., PloS one 2007 (Adenocarcinoma...) : Inhibiting ERK and JNK pathways significantly reduced PAI and uPA induction and inhibited the invasive cell phenotype
Fuhrman et al., Atherosclerosis 2007 (Atherosclerosis...) : Finally, uPA was found to activate MAP-kinase through PI3 kinase (PI3K), as PI3K inhibition abrogated both uPA induced ERK phosphorylation and cholesterol biosynthesis
Sahores et al., Biochim Biophys Acta 2008 : We have also tested uPA induced ERK phosphorylation in the presence of methyl-beta-cyclodextrin, which is known to disrupt lipid rafts by sequestering cholesterol from such domains
Liu et al., Am J Physiol Cell Physiol 2008 : uPA dependent ERK activation and uPAR internalization regulate cell survival and migration ... In a 2-D system, we found that exogenous uPA induced ERK phosphorylation and uPAR internalization were blocked by HKa ... In a 3-D system, we found that not only uPA-uPAR association but also the activation of ERK were inhibited by HKa
Armstead et al., Brain Res 2008 (Hypercapnia...) : Exogenous uPA administered at 4 h post H/I further stimulated ERK MAPK phosphorylation, which was blocked by RAP
Cheng et al., Mol Cell Biochem 2009 : After administration of inhibitors including U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ), SP600125 ( JNK1/2 inhibitor ), CsA ( calcineurin inhibitor ), and QNZ ( NFkappaB inhibitor ), the LPS upregulated expression and/or activity of uPA , MMP-2, and MMP-9 in H9c2 cardiomyoblasts are markedly inhibited only by ERK1/2 inhibitors, U0126
Maupas-Schwalm et al., Cell Signal 2009 : We report that uPA , as well as its catalytically inactive N-amino fragment ATF, triggers the sequential activation of MMP-2, NSMase-2 and ERK1/2 in ECV304 cells that are required for uPA induced ECV304 proliferation, as assessed by the inhibitory effect of Marimastat ( a MMP inhibitor ), MMP-2-specific siRNA, MMP-2 defect, and NSMase-specific siRNA
Kim et al., Cryobiology 2010 : These results suggest that ROS/ERK mediated uPA activation may be an important factor in cryo-damage of primary uterine cells
Liu et al., Cancer Sci 2010 (Neoplasm Invasiveness...) : Both ERK and JNK inhibitors significantly inhibited hypoxia induced expression of 67LR and the subsequent expression of uPA and MMP 9 ... Taken together, these results reveal that 67LR promotes the invasive and metastatic ability of the gastric cancer cells through increasing uPA and MMP 9 expression, with involvement of the ERK and JNK signal pathway in hypoxia induced 67 LR expressions and subsequent uPA and MMP9 expression
Nalla et al., Cell Signal 2011 (Meningeal Neoplasms...) : Downregulation of uPA and uPAR, simultaneously by transfecting the cancer cells with bi-cistronic siRNA expressing plasmid ( pU ) inhibited radiation induced ERK activation, nuclear translocation of Rel-A, NF-?B DNA binding activity, and MCP-1 expression
Velpula et al., Neoplasia (New York, N.Y.) 2013 (Brain Neoplasms...) : Analysis on signaling events demonstrated the activation of MAP kinase kinase ( MEK ) -extracellular signal regulated kinase ( ERK ) in radiation treated cells, while U0126 ( MEK/ERK inhibitor ) blocked hypomethylation, recruitment of SP1, and uPA expression