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FOXO3 — PTEN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: FOXO3 → PTEN (increases, PTEN Activity)
  Evidence: In PTEN-deficient prostate carcinoma cell lines, FOXO1 and FOXO3 are cytoplasmically sequestered and inactive (Modur et al., 2002). In addition, the expression level of tumor necrosis factor family member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; Modur et al., 2002), a proapoptotic effector, is decreased (Modur et al., 2002).

Text-mined interactions from Literome

Li et al., J Cereb Blood Flow Metab 2009 (Hypoxia-Ischemia, Brain) : Furthermore, we found that PTEN inhibition by bisperoxovanadium significantly increased the phosphorylation of Akt and FOXO3a , decreased the nuclear translocation of FOXO3a, and inhibited Bim expression after HI
Vahtola et al., Cardiovascular diabetology 2010 (Diabetes Complications...) : In the GK rat myocardium, Akt- and FOXO3a-phosphorylation was decreased and nuclear localization of FOXO3a was increased concomitantly with increased PTEN protein expression
Dai et al., Cancer Res 2010 (Brain Neoplasms...) : Decreased PTEN in turn resulted in the hyperactivation of Akt, which led to phosphorylation and cytoplasmic retention of FoxO3a
Weidinger et al., J Clin Endocrinol Metab 2011 (Carcinoma...) : In vivo, we observed a direct correlation between PTEN expression and the transcriptional activation of FOXO3
Luo et al., Cell death & disease 2013 (Colorectal Neoplasms) : PTEN regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species mediated apoptosis in selenite treated colorectal cancer cells ... Additionally, we discovered that FoxO3a mediated upregulation of PTEN exerted a further inhibitory effect on the AKT survival pathway