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ANGPT2 — ANXA6
Text-mined interactions from Literome
Hafizi et al., Am J Physiol Heart Circ Physiol 2004
:
In conclusion, we have shown that
ANG II activates components of the rapamycin-sensitive mTOR signaling pathway in human cSMCs and
involves activation of phosphatidylinositol 3-kinase,
p70 ( S6k ), and eukaryotic initiation factor-4E, which leads to activation of protein synthesis
Kim et al., Am J Physiol Endocrinol Metab 2012
:
From these results, we conclude that
activation of
mTOR/p70S6K by
ANG II in vascular endothelium may contribute to impairment of insulin stimulated vasodilation through phosphorylation of IRS-1 at Ser ( 636/639 )
Sadoshima et al., Circ Res 1995
(Cardiomegaly) :
Using cultured neonatal rat ventricular myocytes, we examined whether
Ang II activates
p70S6K and investigated the effect of rapamycin, a potent yet indirect inhibitor of p70S6K, on the Ang II-induced hypertrophic response
Takano et al., FEBS Lett 1996
(Cardiomegaly) :
In the present study, we have examined whether
Ang II activates
p70 S6 kinase (p70S6K) , which has been reported to phosphorylate S6 protein ...
Ang II activated
p70S6K through AT1 receptor
Graves et al., J Biol Chem 1997
:
These results show that in GN4 cells,
Ang II selectively
activates p70 ( S6K ) through effects on calcium, p90 ( RSK ) through effects on protein kinase C ... The
activation of
p70 ( S6K ) by calcium stimuli or
Ang II was independent of calmodulin but correlated well with the activation of the recently identified, nonreceptor calcium dependent tyrosine kinase ( CADTK ) /PYK-2 ... Both calcium- and
Ang II-dependent activation of
p70 ( S6K ) were attenuated by the tyrosine kinase inhibitor genistein, and activation of p70 ( S6K ) was higher in GN4 than WB cells, correlating with the increased expression and activation of CADTK/PYK-2 in GN4 cells