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EPHB2 — MAP2K7
Text-mined interactions from Literome
Meerzaman et al., Am J Physiol Lung Cell Mol Physiol 2001
:
The activation of
ERK2 was completely blocked either by a dominant negative Ras mutant or in the
presence of a
mitogen activated protein kinase kinase ( MEK ) inhibitor
Bobrovskaya et al., J Neurochem 2001
(MAP Kinase Signaling System) :
The inhibitors of
mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) activation, PD98059 ( 0.1-50 microM ) and UO126 ( 0.1-10 microM ), dose-dependently
inhibited both
ERK2 and Ser31 phosphorylation on TOH in response to AII, suggesting MEK1/2 involvement
Wang et al., J Hepatol 2002
(MAP Kinase Signaling System) :
PD 98059, a
mitogen activated protein kinase kinase inhibitor, and glutathione, an anti-thiol-oxidant, not only
blocked Cpd 5-induced
ERK phosphorylation, but also antagonized the activation of CPP-32, the altered Bcl-2/Bax expression, and DNA fragmentation
Utsugi et al., Eur J Pharmacol 2002
:
Furthermore,
mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ),
blocked the lipopolysaccharide induced p44/42
ERK activation and PDGF production
Suthiphongchai et al., Oncol Res 2003
(Adenocarcinoma...) :
Inhibition of
mitogen activated protein kinase kinase 1 ( MEK1 ), an upstream
regulator of
ERK1/2 , with PD98059 resulted in a dose dependent reduction of invasiveness with different IC50 values in the three Dunning cell lines
Ohnishi et al., J Biol Chem 2004
:
However, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ( MEK1 ),
inhibited ERK activation by TGF-beta(1), and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs
Song et al., J Leukoc Biol 2004
:
Constitutively active
mitogen activated protein kinase kinase ( MEK ) induced MIP-1alpha, and Ras dominant negative ( DN )
inhibited IC-induced
ERK phosphorylation and MIP-1alpha production
Raines et al., Biochem J 2006
:
Ca2+ mediated
ERK1/2 activation in NO* producing cells could be
restored by exogenous expression of constitutively active
mitogen activated protein kinase kinase 1
Chen et al., J Neurochem 2008
:
Although
mitogen activated protein kinase kinase ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074, pharmacological inhibition of
MEK-ERK signaling by U0126 or PD98059 does not
reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway
Ko et al., Carcinogenesis 2008
(Carcinoma, Non-Small-Cell Lung...) :
Enhancement of
ERK1/2 signaling by constitutively active
mitogen activated protein kinase kinase 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells
Lorenz et al., Nat Med 2009
(Cardiomegaly...) :
ERK1/2 is
activated by
mitogen activated protein kinase kinase-1 ( MEK1 ) and MEK2 ( commonly referred to as MEK1/2 ) -dependent phosphorylation in the TEY motif of the activation loop, but how ERK1/2 is targeted toward specific substrates is not well understood
Huang et al., Carcinogenesis 2009
(Glioma) :
U-0126, the
mitogen activated protein kinase kinase ( MAPK kinase ) inhibitors
blocked ERK activation and cell proliferation induced by diazoxide
Petecchia et al., Chest 2009
(MAP Kinase Signaling System) :
The involvement of epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase ( ERK ) 1/2 cascade in CSC induced damage was shown by the observation that exposure to CSC ( 5 % ) induced a marked phosphorylation of ERK1/2, already detectable after 5-min incubation and confirmed by the demonstration that not only
ERK1/2 phosphorylation but also CSC induced TJ disassembly and DNA fragmentation were partially
inhibited by a
mitogen activated protein kinase kinase inhibitor ( U0126 ) and completely blocked by a EGFR inhibitor ( AG1478 )
Luo et al., Oncogene 2011
:
Ectopic expression of constitutively active
mitogen activated protein kinase kinase 1 ( MKK1 )
resulted in activation of
ERK1/2 and partially prevented CPX inhibition of LEC tube formation
Yang et al., Genetics and molecular research : GMR 2012
(MAP Kinase Signaling System) :
Constitutive activation of the
mitogen activated protein kinase kinase 1 ( CaMEK ) can
promote ERK1/2 expression, which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury
Ludwig et al., J Biol Chem 1998
:
ERK activation is strongly
enhanced by overexpression of p38 and
mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580