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FGF23 — PHEX

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: FGF23 — PHEX (in vitro) Bowe et al., Biochem Biophys Res Commun 2001*
• IRef Ophid Interaction: FGF23 — PHEX (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Liu et al., J Biol Chem 2003 (Hypophosphatemia) : To establish the mechanisms whereby Phex regulates FGF23 , we assessed Phex dependent hydrolysis of recombinant FGF23 in vitro and measured fgf23 message levels in the Hyp mouse homologue of XLH ... These findings suggest that Phex , possibly through the actions of unidentified Phex substrates or other downstream effectors, regulates fgf23 expression as part of a potential hormonal axis between bone and kidney that controls systemic phosphate homeostasis and mineralization
Liu et al., Am J Physiol Endocrinol Metab 2006 (Body Weight...) : Surprisingly, eGFP expression was not increased in cell surface osteoblasts, indicating that Phex deficiency is necessary but not sufficient for increased Fgf23 expression in the osteoblast lineage
Liu et al., Am J Physiol Endocrinol Metab 2007 (Disease Models, Animal...) : We found that increased FGF23 expression in Hyp bone results from a local effect of PHEX deficiency, since FGF23 was increased in Hyp osteocytes before and after explantation into WT mice but was not increased in WT osteocytes after explantation into Hyp mice
David et al., American journal of physiology. Renal physiology 2011 (Hypophosphatemia) : In contrast, with wild-type mice, ASARM peptides likely play a bone PHEX dependent role in renal phosphate regulation and FGF23 expression
Martin et al., FASEB J 2011 : Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in equivalent intrinsic bone mineralization defects and increased Fgf23 expression in osteocytes ... The mechanisms whereby PHEX and DMP1 regulate Fgf23 expression are unknown ... We examined the possibility that PHEX and DMP1 regulate Fgf23 through a common pathway by analyzing the phenotype of compound Phex and Dmp1 mutant mice ( Hyp/Dmp1 ( -/- ) )
Michigami et al., Clinical calcium 2012 : It is suggested that DMP1 and PHEX negatively regulate the expression of FGF23 , although the underlying mechanisms remain to be elucidated