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ABCA1 — IL10

Text-mined interactions from Literome

Rubic et al., Cardiovasc Res 2006 (Atherosclerosis) : Experiments with inhibitors, LXRalpha silencing and the LXRE reporter gene construct supported the proximal transmission of the IL-10 effect on ABCA1 by the IL-10 receptor/signal transducer and activator of transcription 3 ( STAT3 ) pathway and distal cross-talk to the LXRalpha and PPARalpha/retinoic acid X receptor (RXR) and cAMP/protein kinase A (PKA) pathways
Mei et al., Cell Biol Int 2007 : This study investigates the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) on ABCA1 expression and cholesterol content in THP-1 macrophage derived foam cells ... In addition IL-10 time-dependently decreased cholesterol accumulation by up-regulating ABCA1 expression and inhibited the down-regulation of ABCA1 by TNF-alpha in THP-1 macrophage derived foam cells, which may be one of the mechanisms of IL-10 contributing to its anti-atherosclerotic action