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HIF1A — HIF1AN

Pathways - manually collected, often from reviews:

• Reactome Reaction: HIF1A → HIF1AN (reaction) Hewitson et al., J Biol Chem 2002, Lando et al., Genes Dev 2002, Metzen et al., J Cell Sci 2003, Lancaster et al., Biochem J 2004*
• WikiPathways Photodynamic therapy-induced HIF-1 survival signaling: HIF1AN → HIF1A (inhibition)
• WikiPathways miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma : HIF1AN → HIF1A (mim-inhibition)
• WikiPathways miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma : HIF1AN → HIF1A (mim-inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HIF1A — HIF1AN (physical association, affinity chromatography technology) Luo et al., J Biol Chem 2010
• IRef Biogrid Interaction: HIF1A — HIF1AN (direct interaction, pull down) Liu et al., Mol Cell 2007
• IRef Biogrid Interaction: HIF1A — HIF1AN (direct interaction, enzymatic study) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — HIF1AN (direct interaction, pull down) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — HIF1AN (physical association, affinity chromatography technology) Lee et al., Carcinogenesis 2009*
• IRef Biogrid Interaction: HIF1A — HIF1AN (physical association, affinity chromatography technology) Mahon et al., Genes Dev 2001
• IRef Biogrid Interaction: HIF1A — HIF1AN (direct interaction, pull down) Mahon et al., Genes Dev 2001
• IRef Hprd Interaction: HIF1A — HIF1AN (two hybrid) Mahon et al., Genes Dev 2001, Linke et al., J Biol Chem 2004*, Cho et al., FEBS Lett 2007*
• IRef Hprd Interaction: HIF1A — HIF1AN (in vivo) Mahon et al., Genes Dev 2001, Linke et al., J Biol Chem 2004*, Cho et al., FEBS Lett 2007*
• IRef Hprd Interaction: HIF1A — HIF1AN (in vitro) Mahon et al., Genes Dev 2001, Linke et al., J Biol Chem 2004*, Cho et al., FEBS Lett 2007*
• IRef Innatedb Interaction: HIF1A — HIF1AN (unknown, -) Scholz et al., Proc Natl Acad Sci U S A 2013
• IRef Intact Interaction: HIF1A — HIF1AN (direct interaction, x-ray crystallography) Elkins et al., J Biol Chem 2003*
• IRef Intact Interaction: HIF1A — HIF1AN (physical association, anti bait coimmunoprecipitation) Seo et al., FEBS Lett 2009*
• IRef Ophid Interaction: HIF1A — HIF1AN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Park et al., Mol Cell Biol 2003 (Hypoglycemia) : We show that the factor inhibiting HIF-1 can selectively inhibit the transcriptional activity of HIF-1alpha but has no effect on HIF-2alpha mediated transcription in MEFs
Tan et al., Breast Cancer Res 2007 (Breast Neoplasms...) : Cellular HIF-1alpha activity is regulated by factor inhibiting hypoxia-inducible factor 1 ( FIH-1 )
Sakamoto et al., J Biol Chem 2009 : Purified Mint3 binds FIH-1 and inhibits the ability of FIH-1 to modify HIF-1alpha in vitro
Berchner-Pfannschmidt et al., Cell Signal 2010 : NO dependent HIF-1alpha accumulation under normoxia was due to direct inhibition of PHDs and FIH-1 most likely by competitive binding of NO to the ferrous iron in the catalytically active center of the enzymes