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Kumura et al., Biosci Biotechnol Biochem 2001 : Expression of beta-casein was observed in the presence of insulin , hydrocortisone, and prolactin whereas transcription of beta-lactoglobulin and lactoferrin occured irrespective of hydrocortisone and prolactin
Kingsley-Kallesen et al., Mol Endocrinol 2002 : This hypothesis was tested using explant cultures derived from the GR-/- transplants in which the mineralocorticoid fludrocortisone was able to synergistically induce beta-casein gene expression in the presence of prolactin and insulin
Choi et al., Mol Endocrinol 2004 : Inhibitors of the phosphatidylinositol 3-kinase, mammalian target of rapamycin, and MAPK pathways block insulin stimulated total protein and beta-casein synthesis but not the synergistic stimulation
Collet et al., J Mol Endocrinol 1992 : Quantification of casein mRNA levels in hormone stimulated mammary gland explants from tammars in late pregnancy suggests that maximal induction of the beta-casein gene is dependent upon prolactin and insulin , while maximal induction of the alpha-casein gene is dependent upon prolactin, insulin and cortisol
Shamay et al., Mol Endocrinol 1992 : In the presence of insulin , hydrocortisone, and PRL, beta-casein and WAP mRNA levels increased in all transgenic pigs
Gibson et al., In Vitro Cell Dev Biol 1991 : These cells are capable of synthesizing and secreting alpha-lactalbumin and alpha-s1-casein when cultured on a collagen matrix in the presence of insulin , cortisol, and prolactin
Enami et al., Cancer Lett 1979 : A comparison of the 2 cell culture substrata, plastic culture dish and floating collagen gel, showed that the latter supported a much higher degree of simultaneous casein and MTV production in the presence of insulin , cortisol and prolactin in serum-free culture medium
Yoshimura et al., Endocrinology 1990 : The explants prepared from pregnant mice were cultured first for 4 days under nonlactogenic conditions to reduce the initial level of beta-casein transcripts and then induced to express beta-casein gene in the presence of insulin , hydrocortisone, and PRL for up to 3 days
Johnson et al., Domest Anim Endocrinol 2013 : The bovine mammary alveolar cell-T ( MAC-T ) cell line is able to uniformly differentiate and secrete casein proteins in response to dexamethasone, insulin , and prolactin and is extensively used to study bovine mammary epithelial cell (MEC) function
Hubbard et al., Atherosclerosis 1989 (Hypercholesterolemia) : These results are consistent with our hypothesis that the hypocholesterolemic effects of soybean protein and the hypercholesterolemic effects of casein were mediated by altered levels of insulin and glucagon
Arakawa et al., Exp Cell Res 1985 : Epidermal growth factor (EGF) inhibited casein production and the accumulation of casein mRNA activity induced by insulin (I) , cortisol ( F ) and prolactin (P) in a primary culture of mammary epithelial cells from pregnant mice
Klarlund et al., J Biol Chem 1988 : Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts
Eisenstein et al., Mol Cell Biol 1988 : In the presence of insulin , hydrocortisone, and prolactin, growth of COMMA-D cells on floating collagen gels in comparison with that on a plastic substratum resulted in a 2.5- to 3-fold increase in the relative rate of beta-casein gene transcription but a 37-fold increase in beta-casein mRNA accumulation
Prosser et al., Endocrinology 1987 : Comparison of the roles of insulin and insulin-like growth factor I in casein gene expression and in the development of alpha-lactalbumin and glucose transport activities in the mouse mammary epithelial cell
Perry et al., Proc Natl Acad Sci U S A 1980 : In organ cultures of mammary glands from mice in midpregnancy, addition of both insulin and prolactin induces a marked accumulation of alpha-lactalbumin, whereas the augmentation of casein synthesis requires the presence of insulin , prolactin, and cortisol
Nicholas et al., Biochem Biophys Res Commun 1983 : A number of growth factors can maintain hormonally-responsive epithelium in murine mammary explants as well as insulin, but only insulin can promote the synthesis of casein and alpha-lactalbumin, in the presence of glucocorticoid and prolactin
Terada et al., Horm Metab Res 1983 : Addition of cortisol 21-mesylate at concentrations ranging from 10 ( -8 ) M to 10 ( -6 ) M produced no inhibition of casein synthesis that was induced by glucocorticoid, insulin and prolactin in mammary explants from midpregnant mice
Zick et al., Eur J Biochem 1983 : As with phosphorylation of the insulin receptor, insulin selectively enhanced by 2-3-fold the phosphorylation of tyrosines in casein
Chomczynski et al., Science 1984 : Essential role of insulin in transcription of the rat 25,000 molecular weight casein gene
Taketani et al., Endocrinology 1983 : Mouse mammary epithelial cells cultured on collagen gels multiplied and produced casein and alpha-lactalbumin in response to insulin , cortisol, and PRL
Grunberger et al., Biochem Biophys Res Commun 1983 : Insulin receptor preparations from freshly isolated human mononuclear blood cells were also shown to possess insulin dependent casein and ( T, G ) -A -- L kinase activity
Skarda et al., Endokrinologie 1982 : The effects of insulin , cortisol, prolactin, 3,3',5-triiodo-L-thyronine ( L-T3 ) and progesterone on the synthesis of total protein and casein in mammary explants from pregnant goats were studied
Skarda et al., Reprod Nutr Dev 1982 : Effects of insulin , cortisol and prolactin on lipid, protein and casein syntheses in goat mammary tissue in organ culture
Bolander et al., Proc Natl Acad Sci U S A 1981 : In the presence of cortisol and prolactin, insulin at concentrations as low as 1 ng/ml significantly stimulates casein synthesis in mammary explants from midpregnant mice ; maximal synthesis occurs at 10 ng/ml ... The results demonstrate that, although insulin, epidermal growth factor, and somatomedin C can all function as cell maintenance agents, only insulin , together with cortisol and prolactin, can induce casein mRNA accumulation
Guinard et al., J Dairy Sci 1994 : Mammary blood flow and insulin , prolactin, and growth hormone in plasma were not affected by added casein
Nishikawa et al., Am J Physiol 1994 : PRL-RL and beta-casein mRNA levels in cultured mammary epithelium increased in response to insulin , hydrocortisone, and prolactin, whereas progesterone or EGF caused inhibition
Altiok et al., Mol Cell Biol 1993 : Transcription of the beta-casein gene in mammary epithelial cells is regulated by the lactogenic hormones insulin , glucocorticoids, and prolactin
Lochnan et al., Mol Cell Endocrinol 1995 : Human placental lactogen and bovine PRL could also induce a greater than 10-fold induction, whereas insulin did not significantly stimulate the beta-casein promoter
Sørensen et al., Biochem Biophys Res Commun 1997 : Dominant negative c-src also reduced the ability of insulin , hydrocortisone, and prolactin to induce beta-casein accumulation to levels one-half to one-third that of control cells