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INS — PIKFYVE
Text-mined interactions from Literome
Sbrissa et al., Mol Cell Endocrinol 2001
:
Insulin but not PDGF or EGF stimulation of 3T3-L1 adipocytes markedly
increased the PtdIns 3-P production ( 4.2-fold ) in
PIKfyve immune complexes, primarily as a result of increased PI 3-K intrinsic enzymatic activity
Berwick et al., J Cell Sci 2004
:
We also demonstrate that
PIKfyve is phosphorylated on serine318 in intact cells in
response to
insulin , in a PI3-kinase dependent manner, and that PIKfyve colocalises with a highly motile subpopulation of insulin regulated aminopeptidase (IRAP)/GLUT4 vesicles
Hill et al., Biochem Biophys Res Commun 2010
:
Regulation of
PIKfyve phosphorylation by
insulin and osmotic stress ... We have previously demonstrated that
PIKfyve is phosphorylated in
response to
insulin in a PI3-kinase and protein kinase B (PKB) dependent manner ... Our results confirm, therefore, that
PIKfyve is directly phosphorylated by PKB on a single serine residue in
response to
insulin and are not due to autophosphorylation of the enzyme