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PTGS2 — TLR2

Text-mined interactions from Literome

Chang et al., Mol Pharmacol 2004 : Induction of cyclooxygenase-2 overexpression in human gastric epithelial cells by Helicobacter pylori involves TLR2/TLR9 and c-Src dependent nuclear factor-kappaB activation
Xu et al., Respir Res 2008 (Haemophilus Infections...) : The roles of Toll-like receptor (TLR) 2 and TLR4, well known NTHi recognizing receptor in lung epithelial cell and gram negative bacteria receptor, respectively, on the NTHi induced COX-2 expression were investigated in the HEK293 cells overexpressing TLR2 and TLR4 in vitro and in the mouse model of NTHi induced pneumonia by using TLR2 and TLR4 knock-out mice in vivo
Bansal et al., J Leukoc Biol 2009 (Tuberculosis) : We here demonstrate that M. bovis BCG triggered TLR2 dependent signaling leads to COX-2 and PGE2 expression in vitro in macrophages and in vivo in mice
Park et al., J Dent Res 2010 : Interestingly, histamine synergistically activated TLR2 mediated Cox-2 expression and PGE ( 2 ) production ... Studies on the intra-cellular signaling pathways revealed that p38 activation is required for the synergistic activation of Cox-2 by TLR2 and histamine
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach
Chaturvedi et al., J Biol Chem 2010 (Tuberculosis) : Taken together, our investigation identified PE_PGRS11 as an in vivo expressed immunodominant antigen that plays a crucial role in modulating cellular life span restrictions imposed during oxidative stress by triggering TLR2 dependent expression of COX-2 and Bcl2
Bernard et al., J Immunol 2010 : We hypothesized that Cox-2 is induced by TLR activation and is necessary for optimal AMP production, and that inhibitors of Cox-2 may therefore inhibit antimicrobial action
Joseph et al., Biol Reprod 2013 (Inflammation) : Previously we reported the expression of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), also known as cyclooxygenase 2 (COX-2), in human vaginal cells in response to toll-like receptor ( TLR ) ligands and other proinflammatory stimuli
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2 , TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2) , Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )