Gene interactions and pathways from curated databases and text-mining

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FOS — GCLC

Text-mined interactions from Literome

Li et al., J Cell Physiol 2006 : To determine whether age related activation of ERK1/2-AP-1 signaling is responsible for the up-regulation of GCLC , the MEK inhibitors, PD98059 and U0126, were used to block ERK1/2 in VSMC from old rats
Bergelson et al., Cancer Res 1994 (Carcinoma, Hepatocellular) : We observe that lowering the glutathione levels with buthionine sulfoximine, an inhibitor of gamma-glutamylcysteine synthetase , or diamide, a thiol oxidizing agent, stimulates both basal and chemical-inducible expression of chloramphenicol acetyltransferase activity from EpRE Ya-cat and the AP-1 binding activity