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DVL2 — RAC1

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: DVL1/DVL2/DVL3 → RAC1/RAC2/RAC3 (protein-protein, indirect effect)
• NCI Pathway Database Noncanonical Wnt signaling pathway: RAC1/GDP complex (RAC1) → DVL (DVL3/DVL1/DVL2) (modification, collaborate) Zhang et al., J Biol Chem 2001*, Nishita et al., Mol Cell Biol 2010
• NCI Pathway Database Noncanonical Wnt signaling pathway: RAC1/GDP complex (RAC1) → WNT5A/FZD2/ROR2(dimer)/DVL2 complex (WNT5A-FZD2-ROR2-DVL2) (modification, collaborate)
  Sato et al., EMBO J 2010
• NCI Pathway Database Noncanonical Wnt signaling pathway: WNT5A/FZD2/ROR2(dimer)/DVL2 complex (WNT5A-FZD2-ROR2-DVL2) → RAC1/GTP complex (RAC1) (modification, activates) Sato et al., EMBO J 2010
• Reactome Reaction: DVL2 → RAC1 (reaction) Yamanaka et al., EMBO Rep 2002*, Habas et al., Cell 2001, Habas et al., Genes Dev 2003*, Rosso et al., Nat Neurosci 2005*, Heasman et al., Nat Rev Mol Cell Biol 2008*, Lai et al., Cell Res 2009*, Čajánek et al., Mol Cell Biol 2013*, Boutros et al., Cell 1998*, Axelrod et al., Genes Dev 1998*
• Reactome Reaction: DVL2 → RAC1 (indirect_complex) Yamanaka et al., EMBO Rep 2002*, Habas et al., Cell 2001, Habas et al., Genes Dev 2003*, Rosso et al., Nat Neurosci 2005*, Heasman et al., Nat Rev Mol Cell Biol 2008*, Lai et al., Cell Res 2009*, Čajánek et al., Mol Cell Biol 2013*, Boutros et al., Cell 1998*, Axelrod et al., Genes Dev 1998*
• WikiPathways Wnt Signaling Pathway: DVL1/DVL2/DVL3 → Complex of RHOA-RAC1 (activation)
• WikiPathways DNA Damage Response (only ATM dependent): DVL2/DVL3/DVL1 → Complex of RHOA-RAC1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: DVL2 — RAC1 (in vivo) Habas et al., Genes Dev 2003*
• STRING interaction: DVL2 — RAC1 (interaction, mapped from bind)
• STRING interaction: RAC1 — DVL2 (interaction, mapped from grid bind pdb reactome mint intact)

Text-mined interactions from Literome

Rosso et al., Nat Neurosci 2005 : In contrast, Wnt7b and Dvl activate Rac and JNK in hippocampal neurons
Nishita et al., Mol Cell Biol 2010 : We further show that polymerized Dvl is colocalized with Rac1 and that suppressed expression of Rac1 inhibits Wnt5a induced AP-1 activation
Čajánek et al., Mol Cell Biol 2013 (Wnt Signaling Pathway) : Next, we show that Tiam1, a Rac1 guanosine exchange factor (GEF), is expressed in the ventral midbrain, interacts with Dvl, facilitates Dvl-Rac1 interaction, and is required for Dvl- or Wnt5a induced activation of Rac1
Zhu et al., Cell Signal 2013 (Breast Neoplasms) : Rab35 is required for Wnt5a/Dvl2 induced Rac1 activation and cell migration in MCF-7 breast cancer cells