Yang et al., FASEB J 2006
(MAP Kinase Signaling System) :
CSE mediated apoptosis was associated with an increased ERK and p38 MAPK activation , up-regulation of p21 ( Cip/WAK-1 ), and down-regulation of cyclin D1 expression
Thoms et al., Cancer Res 2007
(Colorectal Neoplasms...) :
Indeed, chemical p38 inhibition ( PD169316 ) and small interfering RNA directed against p38 blocked aspirin induced cyclin D1 degradation, nucleolar translocation of RelA, and apoptosis
Recchia et al., Int J Biochem Cell Biol 2009
(Lung Neoplasms...) :
A cross-talk between the androgen receptor and the epidermal growth factor receptor leads to p38MAPK dependent activation of mTOR and cyclinD1 expression in prostate and lung cancer cells