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FOXM1 — PTGS2
Text-mined interactions from Literome
Wang et al., Oncogene 2008
(Adenoma...) :
Cell culture experiments with A549 human lung adenocarcinoma cells demonstrated that depletion of
Foxm1 by either short interfering RNA transfection or treatment with Foxm1 inhibiting ARF 26-44 peptide significantly
reduced Cox-2 expression ... In co-transfection experiments,
Foxm1 protein
induced Cox-2 promoter activity and directly bound to the -2566/-2580 bp region of human Cox-2 promoter
Xu et al., Mol Cancer Res 2013
(Glioma) :
In addition, more detailed analysis revealed the
involvement of
FOXM1 , a member of the forkhead box family of transcriptional activators, in EGF dependent
COX-2 induction