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PTGS2 — VEGFC

Text-mined interactions from Literome

Timoshenko et al., Br J Cancer 2006 (Breast Neoplasms) : COX-2 mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer ... Present study utilized several human breast cancer cell lines ( MCF-7, T-47D, Hs578T and MDA-MB-231, varying in COX-2 expression ) as well as 10 human breast cancer specimens to examine the roles of COX-2 and prostaglandin E ( EP ) receptors in VEGF-C expression or secretion, and the relationship of COX-2 or VEGF-C expression to lymphangiogenesis ... These results, for the first time, demonstrate a regulatory role of COX-2 in VEGF-C synthesis ( and thereby lymphangiogenesis ) in human breast cancer, which is mediated at least in part by EP1/EP4 receptors
Siironen et al., Endocr Relat Cancer 2006 (Carcinoma, Papillary...) : In cell culture, this correlation was not so clear, because the COX-2 selective inhibitor, NS-398, did not reduce VEGF-C expression
Da et al., Arch Med Res 2008 (Lymphatic Metastasis...) : COX-2 mediated VEGF-C overexpression might promote lymphatic invasion via lymphangiogenesis pathway in patients with gastric cancer
Liu et al., Anat Rec (Hoboken) 2009 (Adenocarcinoma...) : Taken together, our results suggest that the differential expression of COX-2 and VEGF-C might help explain the different metastasis phenotype of lung adenocarcinoma cancer, and that COX-2 inhibitor mediates VEGF-C to block lymphangiogenesis and lymph node metastasis
Chien et al., Carcinogenesis 2009 (MAP Kinase Signaling System...) : COX-2 induction by VEGF-C was also observed in other VEGF-R3 ( + ) human AML cell lines ( U937 and HL60 ) ... Blocking the p42/44 mitogen activated protein kinase ( MAPK ) pathway with the MAPK kinase inhibitor, PD 98059, failed to inhibit VEGF-C mediated COX-2 expression ... However, VEGF-C induced COX-2 upregulation was effectively abolished by overexpression of dominant negative c-Jun N-terminal kinase (JNK) or treatment with the JNK inhibitor, SP 600125
Yi et al., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010 (Nasopharyngeal Neoplasms) : LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression, may contribute to lymph metastasis and develop NPC
Liu et al., Microvasc Res 2011 (Lymphatic Metastasis...) : However, little is known about the regulation of VEGF-C by COX-2 in cervical cancer ... In addition, we used the HeLa cervical cancer cell line to explore the in vitro regulation of VEGF-C by COX-2 and its metabolite, PGE ( 2 ), using siRNA mediated gene silencing and EP receptor blockade
Yiannakopoulou et al., J Clin Pharmacol 2012 : The few identified experimental trials indicated that aspirin and other NSAIDs inhibit lymphangiogenesis, with a potential decrease in metastatic spread, possibly through COX-II dependent regulation of VEGF-C expression