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PAK1 — RHO

Text-mined interactions from Literome

Carter et al., Clin Cancer Res 2004 (Adenoma...) : Pak-1 is activated by the Rac, Rho , and Cdc42 small GTPases in response to a variety of stimuli including ras and phosphatidylinositol 3'-kinase/AKT pathway activation
Pandey et al., Blood Cells Mol Dis 2007 (Calcium Signaling) : During LPA ( 0.1 microM ) -induced shape change, a rapid Rho-kinase activation and a slower activation of PAK were observed
Thirone et al., Am J Physiol Cell Physiol 2009 : Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Malecka et al., J Biol Chem 2013 : Synergistic Activation of p21 activated Kinase 1 by Phosphatidylinositol 4,5-Bisphosphate and Rho GTPases