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RAC1 — ROCK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Osteopontin-mediated events: ROCK2 (ROCK2) → Rho Family GTPase-active (RHOA/CDC42/RAC1) (modification, collaborate)
  Chellaiah et al., J Biol Chem 2003
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Osteopontin-mediated events: Rho Family GTPase-active (RHOA/CDC42/RAC1) → CD44/Rho Family GTPase/ROCK2 complex (CD44-ROCK2) (modification, collaborate)
  Chellaiah et al., J Biol Chem 2003
  Evidence: assay, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 23 proteins (association, tandem affinity purification) Villacé et al., Nucleic Acids Res 2004
• STRING interaction: ROCK2 — RAC1 (interaction, mapped from grid bind mint intact)
• STRING interaction: RAC1 — ROCK2 (interaction, mapped from grid bind mint intact)

Text-mined interactions from Literome

Stuart et al., J Biol Chem 2008 (Neoplasms) : We show here that activated RhoA, but not Rac1 , is enriched in pseudopodia of MSV-MDCK-INV tumor cells and that Rho, Rho kinase ( ROCK ), and myosin II regulate the microtubule independent targeting of RNA to these tumor cell domains
Thirone et al., Am J Physiol Cell Physiol 2009 : Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Vega et al., J Cell Biol 2011 (Breast Neoplasms...) : We propose that RhoA contributes to migratory cell polarity through ROCK2 mediated suppression of Rac1 activity in lamellipodia, whereas RhoC promotes polarized migration through FMNL3 by restricting lamellipodial broadening
de Toledo et al., PloS one 2012 : Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity
Zheng et al., J Biomed Mater Res A 2013 : These results indicate that upregulated RhoA/ROCK activity suppresses Rac1 activity to decrease the motility of osteoblasts on a rough surface at nanometer dimensions, and the low motility of osteoblasts on a rough surface at nanometer dimensions can be reversed by ROCK inhibition
Tsygankova et al., J Biol Chem 2013 (Neoplasm Invasiveness...) : Inhibition of Rac1 activity restored membrane blebbing and increased ROCK activity in Rap1GAP depleted cells, suggesting that Rac1 contributes to the suppression of contractility
Zong et al., J Biol Chem 1999 : Rac to Rho point mutations ( V85D or A88D ) within loop 6 of Rac promoted its association with PRK2 and ROCK , whereas the reciprocal Rho ( D87V/D90A ) double mutant significantly reduced effector binding capacity