Matsuzaki et al., Oncogene 2004
:
However, the expression of dominant negative c-Jun ( TAM-67 ) did not inhibit the action of TPA on p18(INK4c) Jalili et al., J Natl Cancer Inst 2012
(MAP Kinase Signaling System...) :
Using a dominant negative approach, in vitro cell proliferation assays, western blots, and flow cytometry showed that MAPK signaling via BRAF ( V600E ) promotes melanoma cell proliferation at G1 through AP-1 mediated negative regulation of the INK4 family member, cyclin dependent kinase inhibitor 2C ( CDKN2C ), and the CIP/KIP family member, cyclin dependent kinase inhibitor 1A ( CDKN1A )