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CDKN2B — MYC

Pathways - manually collected, often from reviews:

• KEGG TGF-beta signaling pathway: MYC → CDKN2B (protein-protein, inhibition)
• NCI Pathway Database Regulation of nuclear SMAD2/3 signaling: MYC/MIZ-1 complex (MYC-ZBTB17) → p15INK4b (CDKN2B) (transcription, inhibits) Feng et al., EMBO J 2000, Seoane et al., Nat Cell Biol 2001, Matsuura et al., Nature 2004
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Staller et al., Nat Cell Biol 2001 : Repression of p15INK4b expression by Myc through association with Miz-1 ... Expression of Myc in primary cells inhibits the accumulation of p15INK4b that is associated with cellular senescence ; conversely, deletion of c-myc in an established cell line activates p15INK4b expression
Orian et al., Science's STKE : signal transduction knowledge environment 2001 : Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15(INK4b) , and how TGF-beta is able to unblock Myc dependent repression of Miz-1
Feng et al., Mol Cell 2002 : Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta mediated induction of the CDK inhibitor p15(Ink4B) ... Through its direct interaction with Smads, c-Myc binds to the Sp1-Smad complex on the promoter of the p15(Ink4B) gene, thereby inhibiting the TGF-beta induced transcriptional activity of Sp1 and Smad/Sp1 dependent transcription of the p15(Ink4B) gene
Inoue et al., Genes Dev 2013 (Cell Transformation, Neoplastic...) : Notably, in the absence of Mule, c-Myc/Miz1 transcriptional complexes accumulated, and levels of p21CDKN1A ( p21 ) and p15INK4B ( p15 ) were down-regulated