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KAT5 — SIRT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yamagata et al., Biochem Biophys Res Commun 2009
:
Moreover, Sirt1 deacetylates an acetylated Tip60 in response to DNA damage and stimulates proteasome dependent Tip60 degradation in vivo, suggesting that
Sirt1 negatively
regulates the protein level of
Tip60 in vivo
Peng et al., Mol Cell Biol 2012
:
Together, these findings uncover novel pathways in which
SIRT1 dynamically interacts with and
regulates hMOF and
TIP60 through deacetylation and provide additional mechanistic insights by which SIRT1 regulates DNA damage response