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LRP5 — VDR
Text-mined interactions from Literome
Fretz et al., Mol Endocrinol 2006
:
Importantly, this interaction between 1,25- ( OH ) 2D3 activated
VDR and the Lrp5 gene
led to both a modification in chromatin structure within the Lrp5 locus and the induction of
Lrp5 mRNA transcripts in vivo as well as in vitro
Fretz et al., J Steroid Biochem Mol Biol 2007
:
Importantly, this interaction between 1,25 ( OH ) ( 2 ) D ( 3 ) -activated
VDR and the Lrp5 gene
led to both a modification in chromatin structure within the Lrp5 locus and the induction of
LRP5 mRNA transcripts in vivo as well as in vitro
Haussler et al., J Steroid Biochem Mol Biol 2010
:
1,25D/VDR signaling
regulates the expression of TRPV6, BGP, SPP1,
LRP5 , RANKL and OPG, while achieving feedback control of mineral ions to prevent age related ectopic calcification by governing CYP24A1, PTH, FGF23, PHEX, and klotho transcription