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CEBPB — KLF4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Gonzalez et al., Cell Metab 2005
:
Two new members of this cascade have been uncovered --
Kruppel-like factor 5 (KLF5), which is
induced by
C/EBPbeta and delta and acts in concert with C/EBPalpha, beta, and delta to activate PPARgamma2 expression, and Krox20, which is upstream of C/EBPbeta expression and one of the earliest factors induced during adipogenesis
Birsoy et al., Cell Metab 2008
:
C/EBPbeta knockdown increases levels of KLF4 and Krox20, suggesting that
C/EBPbeta normally
suppresses Krox20 and
KLF4 expression via a tightly controlled negative feedback loop