◀ Back to PTGS2

PTGS2 — TAT

Text-mined interactions from Literome

Flora et al., Neuromolecular Med 2006 (Inflammation) : Cyclooxygenase-2 is involved in HIV-1 Tat induced inflammatory responses in the brain ... Tat induced COX-2 expression was partially prevented by pyrrolidine dithiocarbamate, a potent antioxidant and an inhibitor of the transcription factor, nuclear factor kappaB
Barreto-de-Souza et al., J Infect Dis 2006 (HIV Infections...) : Tat induced cyclooxygenase (COX)-2 expression and prostaglandin E2 ( PGE2 ) synthesis, and a COX-2 inhibitor abolished the Tat mediated augmentation of Leishmania replication
Blanco et al., J Immunol 2008 : Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells ... Moreover, Tat induced COX-2 promoter transcription ... Interestingly, Tat did not induce NF-kappaB activity, suggesting that NF-kappaB was not necessary to control COX-2 transcription induced by Tat ... In contrast, deletion or mutation of the NFAT and/or AP-1 site abrogated COX-2 induction by Tat ... Transfection of a dominant negative c-Jun mutant protein, TAM-67, or of a dominant negative version of NFAT, efficiently blocked the induction of COX-2 promoter by Tat , confirming the requirement of both transcription factors ... Moreover, Tat induced NFAT translocation to the nucleus and binding to the distal site of the COX-2 promoter ... The importance of NFAT and AP-1 in COX-2 induction and PGE2 synthesis by Tat was corroborated by using pharmacological inhibitors of the NFAlphaTau, ERK, and JNK pathways