Casanovas et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
The effect of p38 ( SAPK2 ) on cyclin D1 stability might be mediated by direct phosphorylation at specific sites
Page et al., Am J Physiol Lung Cell Mol Physiol 2001
:
The chemical p38 inhibitors SB-202190 and SB-203580 each increased basal and PDGF induced cyclin D1 promoter activity and protein abundance ... Together, these data demonstrate that p38 negatively regulates cyclin D1 expression
Shen et al., Toxicol Lett 2006
:
These results demonstrate that ERKs and JNKs, but not p38K is responsible for induction of cyclin D1 and CDK4 in S-HELF, suggesting that overexpression of cyclin D1 and CDK4 caused by silica is mediated by ERK, JNK/AP 1signaling pathway
Ostrander et al., Cancer Res 2007
(Breast Neoplasms) :
Furthermore, EGF- and heregulin induced cyclin D1 expression is dependent on p38 signaling and inhibited by Brk shRNA knockdown